Spider Loc was first discovered by Suge Knight and tagged along with Death Row Records but never signed a deal. In September 2004, Spider Loc met rapper Young Buck in Atlanta but he knew him before this and did an accepella for him. A week later in Los Angeles, Young Buck introduced him to 50 Cent on the set of the "Shorty Wanna Ride" video, and he performed the same freestyle. After four months, the rapper signed a record deal and a position with 50's G-Unit.
He has since been featured on many G-Unit mixtapes such as G-Unit Radio Part 18 - Rags To Riches where the Loc was the main subject of the mixtape and has also released his own mixtape with G-Unit West, titled Bangadoshish (LA Kings), which featured artists Young Buck, Big Syke (from Thug Life), 50 Cent and Olivia.
On September 11th 2007, Spider Loc released his debut EP, West Kept Secret: The Prequel. The EP received critical acclaim, with renowned Hip Hop Website Allhiphop.com awarding it eight out of ten stars.
In 2004, Spider Loc first played a small role alongside former Death Row artist Crooked I in Bank Brothers. In 2005, he made his first voice acting 'appearance' as a character on 50 Cent: Bulletproof. In 2006, Spider Loc made his first TV appearance in an episode of Cold Case. 2007 Saw him making more on-screen appearances, firstly by starring in his own small-time movie along with Master P, titled Paroled, as a character named CJ Tillman. Spider Loc went on to play a small role in an episode of Numb3rs as a prisoner, before making an appearance on the hit show Weeds as a character named Two-strikes. Curtis does not have a SAG registration so he is not technically an actor.
He also played a role in the low budget film I Accidentally Doomed Your Son along with Westcoast artist Kurupt of Tha Dogg Pound.
Spider Loc is known for stealing rapper Yukmouth's chain while in a night-club in Hollywood. In a 2006 interview, Spider Loc admitted to a brawl with Yukmouth and his entourage. Spider Loc took pictures wearing Yukmouth's chain and they soon spread across the Internet, starting at indastreets.net. Yukmouth then made a few phone calls and received the chain back the next day. Yukmouth has dissed Spider Loc in many songs like "Aaadadamean" "Playa Hata" and "I'm The Shit."
Recently, Yukmouth claimed that the two have made up and no longer have problems with each other.
Spider Loc also had a feud with ousted G-Unit artist The Game.They have since attacked each other on numerous songs, including Spider Loc's "Bitch Boy" and "I Don't Want No Problems" and also Bitchin'" featuring Mr. Criminal. The Game responded to Spider Loc with the track "Spider Joke (240 Bars)", and Spider Loc responding himself with "G-Unot Killer", "Bang Bang" and "97 Bars" with Snoopy Blue. Snoop Dogg also said in a homemade video that he wants to see a boxing match between Game and Spider Loc.
On April 19, 2007, Spider Loc's video shoot of Blutiful was interrupted by gunfire. The gunfire erupted at the Compton Airport where rival gang members shot 12-rounds of gunfire, some of different caliber, sent the men, women and children, diving for safety.